There is a need to find an effective prevention and/or treatment for ARMD before it evolves to advanced disease. In the normal retina, the RPE performs multiple functions in the retina. During aging and in the presence of disease the robustness of each of these functions diminishes.
Studies of the the RPE indicate that the capacity of the RPE to replace itself in response to injury is compromised with aging.
Loss of telomeric DNA occurs during cell division because the end of the lagging strand of the chromosome cannot be fully replicated. In some cells, this loss is partly or completely restored by telomerase.
1. a complete ophthalmologic examination
2. color photography of the macula
3. optical coherence tomography (OCT) and
4. macular integrity assessment (MAIA) examination (fig B).
This information is not meant to take the place of the informed consent document nor is it a substitute for an open discussion about the study between the participant and the investigators.
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